Structure and transport mechanism of P5B-ATPases

Structure and transport mechanism of P5B-ATPases

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La persona de Matthew McConaughey au début des années 2010 : masculinité, hétérosexualité et blanchité liquides
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lightemupsequences.com
.In human cells, P5B‐ATPases execute export of spermine from lysosomes to the cytosol, but the mechanisms of spermine recognition, uptake and transport remain elusive.Here the authors present cryo‐EM structures of a yeast homolog of human ATP13A2‐5, Ypk9, which depict three separate transport cycle intermediates, including spermine‐bound conformations